KLOTHO polyclonal, anti-human, mouse, rat
€362.00
In stock
SKU
254402
Catalog Nr.: 254402
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC, IF
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC, IF
Protein Family: Enzymes
Pathway and Disease: Carbohydrate Metabolism
Description:
KLOTHO is the systemic anti-aging hormone within the glycosidase 1 superfamily. It encodes a type I membrane protein that is abundant in the kidney and brain. In mice, a deficiency in KLOTHO expression leads to various systemic phenotypes resembling human aging such as arteriosclerosis, osteoporosis, and skin atrophy together with growth retardation, short life-span and infertility. Transgenic mice overexpressing KLOTHO have an extended life span by inhibiting insulin/IGF1 signaling. KLOTHO is involved in the regulation of calcium/phosphorus homeostasis by inhibiting the synthesis of active vitamin D and identified as a potential tumor suppressor.
Alternate Names: KL, KLOTHO
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC:1:100-1:500; IF: 1:50-1:200
Accession No.: NP_004786
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human KLOTHO.
Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Carbohydrate Metabolism
Description:
KLOTHO is the systemic anti-aging hormone within the glycosidase 1 superfamily. It encodes a type I membrane protein that is abundant in the kidney and brain. In mice, a deficiency in KLOTHO expression leads to various systemic phenotypes resembling human aging such as arteriosclerosis, osteoporosis, and skin atrophy together with growth retardation, short life-span and infertility. Transgenic mice overexpressing KLOTHO have an extended life span by inhibiting insulin/IGF1 signaling. KLOTHO is involved in the regulation of calcium/phosphorus homeostasis by inhibiting the synthesis of active vitamin D and identified as a potential tumor suppressor.
Alternate Names: KL, KLOTHO
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC:1:100-1:500; IF: 1:50-1:200
Accession No.: NP_004786
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human KLOTHO.
Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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