KMT1C Antibody (C-term) Blocking peptide
€363.00
In stock
SKU
AC-BP1197b
Background:
BAT8, also known as G9A, is a lysine-preferring histone methyltransferase. H3 Lys-9 methylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. The presence of the ankyrin repeats also suggests that BAT8 is involved in intracellular protein-protein interaction. Like Suv39h1, BAT8 transfers methyl groups to the lysine residues of histone H3, but with a 10- to 20-fold higher activity. BAT8 was able to add methyl groups to lys27 as well as lys9 in histone H3, compared with Suv39h1, which was able only to methylate lys9. BAT8 is localized to the nucleus but not in the repressive chromatin domains of centromeric loci, in which Suv39h1 family proteins were localized. This protein is probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. BAT8 also methylates histone H1.
Other Names:
Histone-lysine N-methyltransferase EHMT2, 211-, Euchromatic histone-lysine N-methyltransferase 2, HLA-B-associated transcript 8, Histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, Lysine N-methyltransferase 1C, Protein G9a, EHMT2, BAT8, C6orf30, G9A, KMT1C, NG36
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP1197b was selected from the C-term region of human BAT8. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: EHMT2
Gene ID: 10919
Primary Accession: Q96KQ7
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
BAT8, also known as G9A, is a lysine-preferring histone methyltransferase. H3 Lys-9 methylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. The presence of the ankyrin repeats also suggests that BAT8 is involved in intracellular protein-protein interaction. Like Suv39h1, BAT8 transfers methyl groups to the lysine residues of histone H3, but with a 10- to 20-fold higher activity. BAT8 was able to add methyl groups to lys27 as well as lys9 in histone H3, compared with Suv39h1, which was able only to methylate lys9. BAT8 is localized to the nucleus but not in the repressive chromatin domains of centromeric loci, in which Suv39h1 family proteins were localized. This protein is probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. BAT8 also methylates histone H1.
Other Names:
Histone-lysine N-methyltransferase EHMT2, 211-, Euchromatic histone-lysine N-methyltransferase 2, HLA-B-associated transcript 8, Histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, Lysine N-methyltransferase 1C, Protein G9a, EHMT2, BAT8, C6orf30, G9A, KMT1C, NG36
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP1197b was selected from the C-term region of human BAT8. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: EHMT2
Gene ID: 10919
Primary Accession: Q96KQ7
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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