(KO Validated) ADRBK1 Polyclonal Antibody

Background:
The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.

Research Area: Cancer, Neuroscience, Signal Transduction

Synonyms:
GRK2, ADRBK1, BARK1, BETA-ARK1

Immunogen: Recombinant fusion protein of human ADRBK1 (NP_001610.2).

Swissprot: P25098
Gene ID: 156

Calculated MW: 79 kDa
Observed MW: 80 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IHC 1:50-1:200"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.