(KO Validated) AK2 Polyclonal Antibody

Background:
Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Mutations in this gene are the cause of reticular dysgenesis. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1 and 2.

Research Area: Cancer, Cell Biology, Metabolism, Signal Transduction

Synonyms:
AK2, ADK2

Immunogen: Recombinant fusion protein of human AK2 (NP_001616.1).

Swissprot: P54819
Gene ID: 204

Calculated MW: 14 kDa/21 kDa/22 kDa/24 kDa/25 kDa/26 kDa
Observed MW: 32 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IHC 1:50-1:200"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.