(KO Validated) BCL10 Polyclonal Antibody

Background:
This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants.

Research Area: Cancer, Cell Biology, Metabolism, Signal Transduction

Synonyms:
BCL10, CARMEN, CIPER, CLAP, IMD37, c-E10, mE10

Immunogen: Recombinant fusion protein of human BCL10 (NP_003912.1).

Swissprot: O95999
Gene ID: 8915

Calculated MW: 26 kDa
Observed MW: 33 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.