(KO Validated) CTCF Polyclonal Antibody
€0.00
In stock
SKU
E-AB-67371
Catalog Number: E-AB-67371
Isotype: Rabbit IgG
Reactivity: human, mouse, rat
Applications: WB
Datasheet, Questions? Contact us!
Isotype: Rabbit IgG
Reactivity: human, mouse, rat
Applications: WB
Datasheet, Questions? Contact us!
Background:
This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Research Area: Cancer, Epigenetics and Nuclear Signaling
Synonyms:
Transcriptional repressor CTCFL, Brother of the regulator of imprinted sites, CCCTC-binding factor, CTCF paralog, CTCF-like protein, Cancer/testis antigen 27, CT27, Zinc finger protein CTCF-T, CTCFL, BORIS
Immunogen: Recombinant protein of human CTCF.
Swissprot: P49711
Gene ID: 10664
Calculated MW: 83 kDa
Observed MW: 140 kDa
Purification Method: Affinity purification
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000"
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Research Area: Cancer, Epigenetics and Nuclear Signaling
Synonyms:
Transcriptional repressor CTCFL, Brother of the regulator of imprinted sites, CCCTC-binding factor, CTCF paralog, CTCF-like protein, Cancer/testis antigen 27, CT27, Zinc finger protein CTCF-T, CTCFL, BORIS
Immunogen: Recombinant protein of human CTCF.
Swissprot: P49711
Gene ID: 10664
Calculated MW: 83 kDa
Observed MW: 140 kDa
Purification Method: Affinity purification
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000"
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
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