(KO Validated) HMGB1 Polyclonal Antibody

Background:
This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein.

Research Area: Cancer, Epigenetics and Nuclear Signaling

Synonyms:
HMG-1, HMG1, HMG3, SBP-1, HMGB1

Immunogen: A synthetic peptide of human HMGB1 (NP_002119.1).

Swissprot: P09429
Gene ID: 3146

Calculated MW: 24 kDa
Observed MW: 29 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:200"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.