(KO Validated) HuR / ELAVL1 Polyclonal Antibody

Background:
The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy.

Research Area: Cancer, Epigenetics and Nuclear Signaling

Synonyms:
ELAV1, HUR, Hua, MelG, HuR / ELAVL1, ELAVL1

Immunogen: Recombinant fusion protein of human HuR / ELAVL1 (NP_001410.2).

Swissprot: Q15717
Gene ID: 1994

Calculated MW: 36 kDa/38 kDa
Observed MW: 37 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IHC 1:100-1:200 IF 1:50-1:200"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.