(KO Validated) LDHB Polyclonal Antibody

Background:
This gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alternatively spliced transcript variants have been found for this gene. Recent studies have shown that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on chromosomes X, 5 and 13.

Research Area: Signal Transduction, Cancer, Kits, Metabolism

Synonyms:
LDHB, HEL-S-281, LDH-B, LDH-H, LDHBD, TRG-5

Immunogen: Recombinant fusion protein of human LDHB (NP_002291.1).

Swissprot: P07195
Gene ID: 3945

Calculated MW: 36 kDa
Observed MW: 37 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.