(KO Validated) NDUFS2 Polyclonal Antibody

Background:
The protein encoded by this gene is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I). Mammalian mitochondrial complex I is composed of at least 43 different subunits, 7 of which are encoded by the mitochondrial genome, and the rest are the products of nuclear genes. The iron-sulfur protein fraction of complex I is made up of 7 subunits, including this gene product. Complex I catalyzes the NADH oxidation with concomitant ubiquinone reduction and proton ejection out of the mitochondria. Mutations in this gene are associated with mitochondrial complex I deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Research Area: Cancer, Cell Biology, Metabolism, Signal Transduction, Tags and Cell Markers

Synonyms:
NDUFS2, CI-49

Immunogen: Recombinant fusion protein of human NDUFS2 (NP_004541.1).

Swissprot: O75306
Gene ID: 4720

Calculated MW: 51 kDa/52 kDa
Observed MW: 49 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:1000-1:3000 IF 1:50-1:200"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.