KRIT1 Antibody (N-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP18206a
Background:
This gene encodes a protein containing four ankyrinrepeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, andmultiple NPXY sequences. The encoded protein is localized in thenucleus and cytoplasm. It binds to integrin cytoplasmicdomain-associated protein-1 alpha (ICAP1alpha), and plays acritical role in beta1-integrin-mediated cell proliferation. Itassociates with junction proteins and RAS-related protein 1A(Rap1A), which requires the encoded protein for maintaining theintegrity of endothelial junctions. It is also amicrotubule-associated protein and may play a role in microtubuletargeting. Mutations in this gene result in cerebral cavernousmalformations. Multiple alternatively spliced transcript variantshave been found for this gene.
Other Names:
Krev interaction trapped protein 1, Krev interaction trapped 1, Cerebral cavernous malformations 1 protein, KRIT1, CCM1
Gene Name: KRIT1
Gene ID: 889
Primary Accession: O00522
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
This gene encodes a protein containing four ankyrinrepeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, andmultiple NPXY sequences. The encoded protein is localized in thenucleus and cytoplasm. It binds to integrin cytoplasmicdomain-associated protein-1 alpha (ICAP1alpha), and plays acritical role in beta1-integrin-mediated cell proliferation. Itassociates with junction proteins and RAS-related protein 1A(Rap1A), which requires the encoded protein for maintaining theintegrity of endothelial junctions. It is also amicrotubule-associated protein and may play a role in microtubuletargeting. Mutations in this gene result in cerebral cavernousmalformations. Multiple alternatively spliced transcript variantshave been found for this gene.
Other Names:
Krev interaction trapped protein 1, Krev interaction trapped 1, Cerebral cavernous malformations 1 protein, KRIT1, CCM1
Gene Name: KRIT1
Gene ID: 889
Primary Accession: O00522
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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