KRT15 (clone 6E7), anti-human
€394.00
In stock
SKU
252936
Catalog Nr.: 252936
Size: 0.1 ml
Isotype: Mouse IgG2a
Applications: WB, FC, IF
Size: 0.1 ml
Isotype: Mouse IgG2a
Applications: WB, FC, IF
Protein Family: Cytoskeleton Proteins
Pathway and Disease: Signaling Molecules and Interaction, Cell Growth and Death
Description:
KRT15 (Cytokeratin-15) is a member of the keratin protein family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Keratin 15 is a type I keratin without a defined type II partner. Keratin 15 is expressed primarily in the basal keratinocytes of stratified tissues, including the fetal epidermis and fetal nail. Expression of keratin 15 is downregulated in some hyperproliferating situations, such as psoriasis and hypertrophic scars. Because keratinocytes in psoriasis and hypertrophic scars are activated, it is suggested that keratin 15 expression is not compatible with keratinocyte activation and the keratin 15 gene is downregulated to maintain the activated phenotype.
Alternate Names: Keratin, type I cytoskeletal 15, Cytokeratin-15, CK-15, Keratin-15, K15, KRTB, KRT15
Application Notes: WB: 1:500-1:2000; IF: 1:200-1:1000; FC: 1:200-1:400
Accession No.: P19012
Antigen: Purified recombinant fragment of KRT15 expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Signaling Molecules and Interaction, Cell Growth and Death
Description:
KRT15 (Cytokeratin-15) is a member of the keratin protein family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Keratin 15 is a type I keratin without a defined type II partner. Keratin 15 is expressed primarily in the basal keratinocytes of stratified tissues, including the fetal epidermis and fetal nail. Expression of keratin 15 is downregulated in some hyperproliferating situations, such as psoriasis and hypertrophic scars. Because keratinocytes in psoriasis and hypertrophic scars are activated, it is suggested that keratin 15 expression is not compatible with keratinocyte activation and the keratin 15 gene is downregulated to maintain the activated phenotype.
Alternate Names: Keratin, type I cytoskeletal 15, Cytokeratin-15, CK-15, Keratin-15, K15, KRTB, KRT15
Application Notes: WB: 1:500-1:2000; IF: 1:200-1:1000; FC: 1:200-1:400
Accession No.: P19012
Antigen: Purified recombinant fragment of KRT15 expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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