Lassa Virus (LASV)-GP1 (clone EBS-I-301), anti-human, other animals

Source:
A BALB/c mouse was immunized with gamma rays inactivated strain LASV.
Fusion partner: Sp2/0.

Specifications:
Lassa virus is a member of the Arenaviridae and causes Lassa fever in predominantly West Afrika. The main reservoir is formed by local rodents. Up to half a million people are estimated to attract the disease yearly and mortality rates may reach as much as 50%. Viral proteins, coded within two ambisense RNA strands, include GP1, GP2, NP, polymerase and Z matrix protein. EBS-I-301 reacts with GP1, which is thought to bind to the host cell α-dystroglycan receptor. Reactivity of EBS-I-301 is confined to isolates from Sierra Leone, Guinea and part of Liberia. Nigerian and South African isolates are usuallynot identified by this antibody. The epitope is different from the epitope recognized by the GP1 antibody EBS-I-302.

Species reactivity:
Positive: (humanand animals subject to infection with)Lassa virus.

Applications:
EBS-I-301 is excellent for immunohistology, immunofluorescence, immunoblotting, immunoprecipitation and ELISA.
ELISA: +
Frozen sections: +
Immunofluorescence: +
Lateral flow: +
Western blot: +

Positive control: Cells, serum or tissues infected with Lassa virus.

References:
- Branco L.M. et al. Virol. J.7:279-298 (2010).
- Ruo S.L et al., J. Gen. Virol.72, 549-555 (1991)