MCR-1 Enzyme Rapid Test CE
€0.00
In stock
SKU
P261105
INTENDED USE
The EZERTM MCR-1 Enzyme Rapid Test is an immunochromatographic assay (ICA) for the qualitative detection of MCR-1 protein in bacterial culture. It’s an in vitro diagnostic test for professional use only.
BACKGROUND
The emergence of antibiotic-resistant bacteria is a major global public health crisis. Colistin is a last line of defense in the antibiotic treatment of bacterial infections, especially those caused by multiple-drug resistant bacteria. However, the efficiency of colistin has been limited by the emergence of the mobilized colistin resistance gene, mcr-1, in China in 20161. This gene has been found on numerous plasmids from diverse pathogen species, and has spread across more than 70 countries on five continents2,3.
Therefore, rapid and accurate detection of MCR-1 protein is crucial for effective treatment of patients and prevention of spread of bacteria carrying the MCR-1 gene, especially in hospitals.
PRINCIPLE
The test is ready to use and is based on a membrane technology with colloidal gold nanoparticles. Our kit is aimed to the detection of MCR-1 protein in bacterial culture.
Nitrocellulose membrane is sensitized with MCR-1 monoclonal antibody (“T” line) and control capture reagent (“C” line).
Monoclonal antibody that individually recognize MCR-1 protein label with colloidal gold and dried on a membrane. When the provided buffer containing the resuspended bacteria comes into contact with the strip, the solubilized antibody-colloidal gold conjugates migrate with the sample by passive diffusion, while conjugates and sample material come into contact with the immobilized MCR-1 protein antibody that are adsorbed onto the nitrocellulose strip. If the sample contains a MCR-1 protein, the complexes made of the conjugates and MCR-1 protein will remain bound to their “T” lines. The migration continues by passive diffusion and both conjugates and sample material come into contact with the (upper) line control reagent that binds a control conjugate (“C” line), thereby producing a red line. The result is visible within 15 minutes in the form of red lines on the strip.
CONTENTS
- Test Device (20 Pcs)
- Extraction Tube with Buffer (20 Pcs)
- Package Insert (1 Pc)
STORAGE CONDITIONS
Test devices must be stored at 2~30°C. DO NOT FREEZE.
The EZERTM MCR-1 Enzyme Rapid Test is an immunochromatographic assay (ICA) for the qualitative detection of MCR-1 protein in bacterial culture. It’s an in vitro diagnostic test for professional use only.
BACKGROUND
The emergence of antibiotic-resistant bacteria is a major global public health crisis. Colistin is a last line of defense in the antibiotic treatment of bacterial infections, especially those caused by multiple-drug resistant bacteria. However, the efficiency of colistin has been limited by the emergence of the mobilized colistin resistance gene, mcr-1, in China in 20161. This gene has been found on numerous plasmids from diverse pathogen species, and has spread across more than 70 countries on five continents2,3.
Therefore, rapid and accurate detection of MCR-1 protein is crucial for effective treatment of patients and prevention of spread of bacteria carrying the MCR-1 gene, especially in hospitals.
PRINCIPLE
The test is ready to use and is based on a membrane technology with colloidal gold nanoparticles. Our kit is aimed to the detection of MCR-1 protein in bacterial culture.
Nitrocellulose membrane is sensitized with MCR-1 monoclonal antibody (“T” line) and control capture reagent (“C” line).
Monoclonal antibody that individually recognize MCR-1 protein label with colloidal gold and dried on a membrane. When the provided buffer containing the resuspended bacteria comes into contact with the strip, the solubilized antibody-colloidal gold conjugates migrate with the sample by passive diffusion, while conjugates and sample material come into contact with the immobilized MCR-1 protein antibody that are adsorbed onto the nitrocellulose strip. If the sample contains a MCR-1 protein, the complexes made of the conjugates and MCR-1 protein will remain bound to their “T” lines. The migration continues by passive diffusion and both conjugates and sample material come into contact with the (upper) line control reagent that binds a control conjugate (“C” line), thereby producing a red line. The result is visible within 15 minutes in the form of red lines on the strip.
CONTENTS
- Test Device (20 Pcs)
- Extraction Tube with Buffer (20 Pcs)
- Package Insert (1 Pc)
STORAGE CONDITIONS
Test devices must be stored at 2~30°C. DO NOT FREEZE.
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