MonoMethyl-UHRF1-K385 Polyclonal Antibody

Background:
This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12.

Research Area: Cancer, Epigenetics and Nuclear Signaling

Synonyms:
UHRF1, ICBP90, Np95, RNF106, TDRD22, hNP95, hUHRF1, huNp95

Immunogen: A synthetic monomethylated peptide around K385 of human UHRF1 (NP_001041666.1).

Swissprot: Q96T88
Gene ID: 29128

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: IF 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.