(Mouse) Epha1 Blocking Peptide (Center)
€363.00
In stock
SKU
AC-BP21159a
Background:
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.
Other Names:
Ephrin type-A receptor 1, mEpha1, Embryonic stem cell kinase, Tyrosine-protein kinase receptor ESK, Epha1, Esk
Target/Specificity:
The synthetic peptide sequence is selected from aa 453-467 of HUMAN Epha1
Gene Name: Epha1
Gene ID: 13835
Primary Accession: Q60750
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.
Other Names:
Ephrin type-A receptor 1, mEpha1, Embryonic stem cell kinase, Tyrosine-protein kinase receptor ESK, Epha1, Esk
Target/Specificity:
The synthetic peptide sequence is selected from aa 453-467 of HUMAN Epha1
Gene Name: Epha1
Gene ID: 13835
Primary Accession: Q60750
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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