(Mouse) Mlf1 Blocking Peptide (Center)
€363.00
In stock
SKU
AC-BP21445c
Background:
Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
Other Names:
Myeloid leukemia factor 1, Hematopoietic lineage switch 7, Myelodysplasia-myeloid leukemia factor 1, Mlf1, Hls7
Target/Specificity:
The synthetic peptide sequence is selected from aa 91-106 of HUMAN Mlf1
Gene Name: Mlf1
Gene ID: 17349
Primary Accession: Q9QWV4
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
Other Names:
Myeloid leukemia factor 1, Hematopoietic lineage switch 7, Myelodysplasia-myeloid leukemia factor 1, Mlf1, Hls7
Target/Specificity:
The synthetic peptide sequence is selected from aa 91-106 of HUMAN Mlf1
Gene Name: Mlf1
Gene ID: 17349
Primary Accession: Q9QWV4
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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