MSH2 polyclonal, anti-human, mouse, rat, monkey

Protein Family: Enzymes

Pathway and Disease: Cancers, Replication and Repair

Description:
DNA mismatch repair protein Msh2 (MSH2) is a component of the post-replicative DNA mismatch repair system (MMR). MSH2 forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) that bind to DNA mismatches and initiate DNA repair. Defects in MSH2 are the cause of hereditary non-polyposis colorectal cancer type 1 and endometrial cancers.

Alternate Names: DNA mismatch repair protein Msh2, MutS protein homolog 2, MSH2

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500

Accession No.: P43246, NP_000242

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human MSH2.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.