MUC1 (clone EBS-T-234), anti-human

Source:
A BALB/c mouse was immunized with human milk fat globule membranes (HMFG).
Fusion partner: NS-1.

Specifications:
EBS-T-234 reacts with the protein core of MUC1, an apical cell side epithelial marker which is upregulated or switched on in the majority of carcinomas. The dominant epitope ofEBS-T-234 is PDTR, located in the VNTR domain of MUC1. Binding of EBS-T-234 to MUC1 is independent from the degree of glycosylation.

Species reactivity:
Positive: human.

Applications:
EBS-T-234 can be used for immunohistochemistry, ELISA and fluorescence tests.
ELISA: +
Flow cytometry: +
Frozen section: +s
Immunofluorescence: +
Paraffin sections: Citrate

Positive control: MCF-7 or MDA-231 cells. Breast, colon, ovarian, endometrial carcinoma.

References:
- Xing, X.P. et al. Mol Immunol. 29(5): 641-650 (1992).
- ISOBM TD-4 Workshop report, Tumor Biol.19(Suppl 1) (1998).
- Karsten, U. et al. Cancer. Res. 58(12): 2541-2549 (1998)