MUC1-GalNAc (clone VU-2G7), anti-human

Source:
A BALB/c mouse was immunized with VNTR 60mer glycosylated synthetic peptide BSA conjugate.
Fusion partner: SP2/0.

Specifications:
VU-2G7 reacts with the protein core of MUC1, an apical cell side epithelial marker which is upregulated or switched on in the majority of carcinomas. The dominant epitope of VU-2G7 includes the PDTR motif, located in the VNTR domain of MUC1. Binding of VU-2G7 is significantly enhanced when the threonine of the PDTR motif bears a GalNAc.

Species reactivity:
Positive: human.

Applications:
VU-2G7 can be used for immunohistochemistry, ELISA and fluorescence tests.
ELISA: +
Flow cytometry: +
Frozen sections: +
Immunofluorescence: +
Paraffin sections: +

Positive control: MCF-7 or MDA-231 cells. Breast, colon, ovarian, endometrial carcinoma.

References:
- Ryuko, K. et al. Tumor Biol.21(4): 197-210 (2000).
- Karsten, U. et al. Cancer. Res. 58(12): 2541-2549 (1998)