NBS1 polyclonal, anti-human, mouse, rat, xenopus

Protein Family: Enzymes

Pathway and Disease: Cancers, Replication and Repair, Signaling Molecules and Interaction

Description:
Nijmegen breakage syndrome protein 1 (NBS1) is a component of the MRE11/RAD50/NBN (MRN) complex, which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. NBS1 modulates the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. Defects in NBS1 are the cause of Nijmegen breakage syndrome, cancer predisposition, and anemia.

Alternate Names: Nibrin, Nijmegen breakage syndrome protein 1, Cell cycle regulatory protein p95, NBN, NBS, NBS1, P95

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500

Accession No.: O60934, NP_002476

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human NBS1.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.