Notch 1 (clone ), anti-human, mouse

Background:
Notch1 is a transmembrane protein functioning in development and the determination of cell fate. During maturation, the notch molecule is cleaved by a furin-like convertase at its extracellular domain. Upon binding to a ligand such as Delta1, or upon extracellular calcium depletion, the carboxy-terminal notch1 fragment is released and further cleaved between Gly1753 and Val1754. The resulting activated cytosolic fragment translocates to the nucleus where it activates transcription.

Alternative Name:
Neurogenic locus notch homolog protein 1, Notch 1, hN1, Translocation-associated notch protein TAN-1, Notch 1 intracellular domain, NICD, NOTCH1, TAN1

Application Dilution: WB: 1:1000-1:2000, IHC/ICC/IF: 1:50-1:200, FC: 1:50-1:100

Specificity: This antibody detects endogenous levels of Notch 1 and does not cross-react with related proteins.

Immunogen:
Recombinant antibody.

MW: ~ 110 kDa

Swis Prot.: P46531

Purification & Purity:
Protein A affinity purified

Format:
Recombinant Rabbit Monoclonal Antibody. 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

For research use only, not for use in diagnostic procedure.