NPM1 monoclonal, anti-human, mouse
€470.00
In stock
SKU
AC-AP53282
Catalog Number: AC-AP55222
Size: 100 µl
Host: Rabbit
Applications: IHC-P, IHC-F, IF, ICC, E
Datasheet
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Size: 100 µl
Host: Rabbit
Applications: IHC-P, IHC-F, IF, ICC, E
Datasheet
Request Information
Background:
Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double- stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation.
Other Names:
B23;MGC104254;NMP1;NO38;NPM 1;NPM;NPM_HUMAN;NPM1;Nucleolar Phosphoprotein B23;Nucleolar protein NO38;Nucleophosmin (nucleolar phosphoprotein B23 numatrin);Nucleophosmin; Nucleophosmin/B23.2;Nucleophosmin/nucleoplasmin family member 1;Nucleoplasmin Family Member 1;Numatrin;OTTHUMP00000161024;OTTHUMP00000161025;OTTHUMP00000223397; OTTHUMP00000223398;TRK fused gene.
Antigen Type: Recombinant Protein
Antigen Type: NPM1
Gene ID: 4869
Primary Accession: P06748
Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double- stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation.
Other Names:
B23;MGC104254;NMP1;NO38;NPM 1;NPM;NPM_HUMAN;NPM1;Nucleolar Phosphoprotein B23;Nucleolar protein NO38;Nucleophosmin (nucleolar phosphoprotein B23 numatrin);Nucleophosmin; Nucleophosmin/B23.2;Nucleophosmin/nucleoplasmin family member 1;Nucleoplasmin Family Member 1;Numatrin;OTTHUMP00000161024;OTTHUMP00000161025;OTTHUMP00000223397; OTTHUMP00000223398;TRK fused gene.
Antigen Type: Recombinant Protein
Antigen Type: NPM1
Gene ID: 4869
Primary Accession: P06748
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