Pan Keratin (clone C-11), anti-human, mouse, rat, bovine, cat, chicken, dog, ferret, goat, guinea pig, kangaroo, marmoset, monkey, rabbit, Xenopus laevis.

Source:
A BALB/c mouse was immunized with a cytoskeleton preparation of human A431 carcinoma cell line.
Fusion partner: P3-X63-Ag8.653.

Specifications:
C11 reacts with keratins : 4,5,6,8,10,13 and 18. This is a broad-spectrum antibody, which has been reported to differentiate epithelial tumors from non-epithelial tumors. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.

Species reactivity:
Positive: cat, chicken, cow, dog, ferret, goat, guinea pig, human, kangaroo, marmoset, monkey, mouse, rabbit, rat, Xenopus laevis.

Applications:
Immunocytochemistry on frozen and paraffin sections. Immunofluorescence tests. Strong reaction in immunoblotting.
Flow cytometry: +
Frozen sections: +
Immunofluorescence: +
Paraffin sections: Citrate/protease
Western blot: +

Positive control: A431 cells, skin, lung.

References:
- Vojtĕšek, B. et al. Folia Biol., 35(6): 373-382, (1989)
- Vojtĕšek, B. et al. Neoplasma37(3): 333-342 (1990).
- Kovařík J. et al. Int.J.Cancer, Suppl. 3: 50-55, (1988).
- Kovařík J. et al. J. Tumor Marker Oncol.5: 219 (1990)