Paxillin Phospho-Regulation Antibody Sampler Kit

Background:
Paxillin is a focal adhesion protein involved in cell adhesion and migration. Phosphorylation of serine and tyrosine sites in paxillin regulates its activity. Serine phosphorylation occurs in response to growth-factor and integrin activation. Both JNK1 and cdc2 kinases can phosphorylate Ser-178, and this phosphorylation may be important for cell migration, while ERK and p38MAPK kinases phosphorylate Ser-83, and this phosphorylation may be important for HGF-induced cell spreading and NGF-induced neurite extension. Tyrosine phosphorylation of paxillin also occurs in response to growth factor and integrin activation. The major sites of tyrosine phosphorylation include Tyr-31 and Tyr-118, and both of these sites may be involved in integrin-mediated cell adhesion.

Buffer/Storage:
Mouse monoclonal and rabbit polyclonal antibodies are supplied in phosphate-buffered saline, 50% glycerol, 1 mg/ml BSA, and 0.05% sodium azide. Store at –20°C. Stable for 1 year.