CD279 (PDCD1) polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS60383
Background:
PDCD1 (Programmed Cell Death-1 protein), also designated CD279, is a type I transmembrane receptor and a member of the immunoglobin gene superfamily. Pdcd-1 contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) within the cytoplasmic domain, which is conserved between the mouse and human homologs. Expression of Pdcd-1 is detected in mouse thymus, and it is induced in stimulated B and T cell lines, where it may play a role in the negative regulation of various immune responses. Receptors such as Pdcd-1 function by recruiting tyrosine phosphatases, including SHP-1 and SHIP, which are responsible for altering various B cell responses. Additionally, in activated lymphocytes, Pdcd-1 mediates the activation of the classical type of programmed cell death.
Alternative Name:
Programmed cell death protein 1, Protein PD-1, hPD-1, CD279, PD1
Application Dilution: WB: 1:500~1:1000
Specificity: PDCD1 polyclonal antibody detects endogenous levels of PDCD1 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human PDCD1.
MW: ~ 32 kDa
Swis Prot.: Q15116
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
PDCD1 (Programmed Cell Death-1 protein), also designated CD279, is a type I transmembrane receptor and a member of the immunoglobin gene superfamily. Pdcd-1 contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) within the cytoplasmic domain, which is conserved between the mouse and human homologs. Expression of Pdcd-1 is detected in mouse thymus, and it is induced in stimulated B and T cell lines, where it may play a role in the negative regulation of various immune responses. Receptors such as Pdcd-1 function by recruiting tyrosine phosphatases, including SHP-1 and SHIP, which are responsible for altering various B cell responses. Additionally, in activated lymphocytes, Pdcd-1 mediates the activation of the classical type of programmed cell death.
Alternative Name:
Programmed cell death protein 1, Protein PD-1, hPD-1, CD279, PD1
Application Dilution: WB: 1:500~1:1000
Specificity: PDCD1 polyclonal antibody detects endogenous levels of PDCD1 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human PDCD1.
MW: ~ 32 kDa
Swis Prot.: Q15116
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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