PE/Cyanine5.5 Anti-Human CD197/CCR7 Antibody [clone G043H7]

Background:
CCR7, also known as CD197, is a chemokine receptor that binds CCL19 and CCL21. CCR7 and its ligands link innate and adaptive immunity by affecting interactions between T cells and dendritic cells and their downstream effect. Nave T cells enter the lymph node through high endothelial venules, which express CCL21. Dendritic cells and macrophages enter the lymph node through afferent lymphatics. The encounter of T cells and dendritic cells in the T cell zone is CCR7-dependent. In addition, during immunological surveillance, B cells recirculate between B-cell-rich compartments (follicles or B cell zones) in secondary lymphoid organs, surveying for antigen. After antigen binding, B cells move to the boundary of B and T zones to interact with T-helper cells; this B cell migration is directed by CCR7 and its ligands. CCR7-positive cancer cell expression has been associated with lymph node metastasis. Product Details

Research Area: Cancer, Immunology, Signal transduction

Synonyms:
CMKBR7, EBI1, EVI1, CCR-7, CDw197
Swissprot: P32248

Buffer: PBS with 0.05% Proclin300, 1% BSA

Storage:
Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.