PE/Cyanine5.5 Anti-Human CD45RO Antibody [clone UCHL1]

Background:
CD45RO is a 180 kD single chain membrane glycoprotein. It is a splice variant of tyrosine phosphatase CD45, lacking the A, B, and C determinants. The CD45RO isoform is expressed on activated and memory T cells, some B cell subsets, activated monocytes/macrophages, and granulocytes. CD45RO enhances both T cell receptor and B cell receptor signaling mediated activation. CD45 and its isoforms non-covalently associate with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4. CD45 has also been reported to bind galectin-1 and CD22. CD45 isoform expression can change in response to cytokines.

Research Area: Cancer, Cardiovascular, Immunology, Neuroscience, Signal transduction, Stem cells
Swissprot: P08575

Buffer: PBS with 0.05% Proclin300, 1% BSA

Storage:
Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.