PE/Cyanine5.5 Anti-Mouse CD122 Antibody [clone 5H4]

Background:
CD122 is a 70-75 kD IL-2 receptor β chain also known as IL-2Rβ, which is also shared by the IL-15 receptor. It is constitutively expressed by NK cells and at lower levels by T cells, B cells, monocytes, and macrophages. The IL-2Rβ chain can combine with either the common γ subunit (γc, CD132) alone or with the γc subunit and the IL-2Rα subunit (CD25) to generate intermediate or high affinity IL-2 receptor complexes, respectively. CD122 expression levels can be upregulated by activation. The 5H4 antibody does not block IL-2 binding to the IL-2 receptor. CD122 is expressed on murine, but not human, CD8+ Tregs involved in the maintenance of T cell homeostasis.

Research Area: Immunology, Signal transduction, Stem cells

Synonyms:
Interleukin-2 receptor subunit beta, Il2rb, IL-2 receptor subunit beta, IL-2R subunit beta, IL-2RB, High affinity IL-2 receptor subunit beta, p70-75, CD122
Swissprot: P16297

Buffer: PBS with 0.05% Proclin300, 1% BSA

Concentration: 0.2 mg/mL

Storage:
Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.