PE/Cyanine7 Anti-Human CD274/PD-L1 Antibody [clone 29E.2A3]
€0.00
In stock
SKU
E-AB-F1133H
Catalog Number: E-AB-F1133H
Reactivity: Human, Clone: 29E.2A3
Isotype: Mouse IgG2b, κ, Conjugation: PE/Cyanine7
Applications: FCM
Datasheet, Questions? Contact us!
Reactivity: Human, Clone: 29E.2A3
Isotype: Mouse IgG2b, κ, Conjugation: PE/Cyanine7
Applications: FCM
Datasheet, Questions? Contact us!
Background:
CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells.
Research Area: Cancer, Immunology
Synonyms:
B7-H1, PD-L1, Programmed cell death ligand 1, B7 homolog 1, B7-H, B7H1, PDL1, PDCD1L1, PDCD1LG1
Swissprot: Q9NZQ7
Buffer: PBS with 0.05% Proclin300, 1% BSA
Storage:
Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
Alternative for product with catalog number:
329717, 329718, 374505, 374506
CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells.
Research Area: Cancer, Immunology
Synonyms:
B7-H1, PD-L1, Programmed cell death ligand 1, B7 homolog 1, B7-H, B7H1, PDL1, PDCD1L1, PDCD1LG1
Swissprot: Q9NZQ7
Buffer: PBS with 0.05% Proclin300, 1% BSA
Storage:
Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
Alternative for product with catalog number:
329717, 329718, 374505, 374506
Is Featured? | No |
---|
Write Your Own Review