PE/Cyanine7 Anti-Mouse CD51 Antibody [clone RMV-7]

Background:
CD51 is a 140 kD protein, also known as αV integrin, vitronectin receptor, and integrin αV. It is a member of the integrin family, expressed on activated T cells, polymorphonuclear granulocytes, platelets, blastocysts, and osteoclasts. CD51 forms heterodimers by association with integrins β1, β3, β5 or β6; these complexes then act as receptors for multiple extracellular matrix proteins (ECM). The αvintegrin heterodimers have varied functions in development, stimulation/activation and homeostasis. The primary ligands for CD51 complexes are fibronectin, fibrinogen, vitronectin, thrombspondin, von Willebrand factor, and CD31. The RMV-7 antibody has been reported to block binding of CD51 to vitronectin, fibronectin, and CD31 in some cell types, as well as blocking LAK cell cytotoxicity.

Synonyms:
Integrin alpha-V , αV integrin, Vitronectin Receptor, Integrin αV chain, ITGAV
Swissprot: P43406

Buffer: PBS with 0.05% Proclin300, 1% BSA

Concentration: 0.2 mg/mL

Storage:
Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.