PE/Cyanine7 Anti-Rat CD44H Antibody [clone OX-49]

Background:
CD44 is an 80-95 kD cell surface glycoprotein. It is expressed on all leukocytes, endothelial cells, hepatocytes, and mesenchymal cells. It is up-regulated when T cells and B cells are activated. It was reported that CD44 is a valuable marker for memory T cells. CD44 is an adhesion molecule involved in leukocyte adhesion and homing to lymphoid organs. The OX-49 antibody reacts with CD44H (known as CD44s) expressed on most leukocytes, except for a subset of B lymphocytes. The epitope recognized by OX-49 antibody has been mapped to a region on both the standard, CD44s, and the splice variant, CD44v, isoforms of CD44. However it was reported that OX-49 antibody cannot detect the CD44V isoform, possibly due to conformational changes in the epitope.

Synonyms:
Pgp-1, H-CAM, CD44s, CD44H

Buffer: PBS with 0.05% Proclin300, 1% BSA

Storage:
Store at 2~8℃ and protected from prolonged exposure to light. Do not freeze.