PE/TR Anti-Human CD279/PD-1 Antibody [clone J116]

PE/TR Anti-Human CD279/PD-1 Antibody [clone J116]

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In stock
SKU
E-AB-F1129P
Catalog Number: E-AB-F1129P
Reactivity: Human, Clone: J116
Isotype: Mouse IgG1, κ, Conjugation: PE/TR
Applications: FCM
Datasheet, Questions? Contact us!
Background:
Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 (B7-H1) and PD-L2 (B7-DC) are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.

Synonyms:
PD-1, Programmed Death-1
Swissprot: Q15116

Buffer: PBS with 0.05% Proclin300, 1% BSA

Storage:
Store at 2~8℃ and protected from prolonged exposure to light. Do not freeze.
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