Polyclonal Anti-PCNA loading control antibody

Background:
Proliferating Cell Nuclear Antigen, commonly known as PCNA, is a protein that acts as a processivity factor for DNA polymerase δ in eukaryotic cells. This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. It induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. And It has to be loaded onto DNA in order to be able to stimulate APEX2.

Immunogen:
A synthetic peptide corresponding to internal residues of human PCNA.

Specificity: Detect the endogenous levels of total PCNA protein.Western Blot (1:5000-20000);

Product Form: Liquid

Storage Instruction:
Store at -20℃ for 1 year. Avoid repeated freeze and thaw cycles.