Prostate Specific Antigen, PSA Human Native Protein (Active)
€0.00
In stock
SKU
BNP1025
Description:
Purified human PSA protein
Background:
Prostate-specific antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), is a glycoprotein enzyme encoded in humans by the KLK3 gene. PSA is an androgen-regulated serine protease produced by both prostate epithelial cells and prostate cancer (PCa) and is the most commonly used serum marker for cancer. It is a member of the tissue kallikrein family, some of the members of which are also prostate specific. PSA is a major protein in semen, where its function is to cleave semenogelins in the seminal coagulum. PSA is secreted into prostatic ducts as an inactive 244-amino acid proenzyme (proPSA) that is activated by cleavage of seven N-terminal amino acids. Measurement of free versus total PSA can increase specificity for PCa. PSA is also widely used to monitor responses to therapy and is under investigation as a therapeutic target.
Synonyms:
Prostate specific antigen, PSA, gamma-seminoprotein, Seminin, Kallikrein-3, P30 antigen, Semenogelase, KLK3, APS
Application: ELISA
Purity: >90% by SDS-PAGE
Formulation: Liquid
Storage buffer: Each vial contains 0.01 M PBS, 0.15 M NaCl (pH 7.4)without preservative.
Storage and Expiration:
Ship at 4℃.Upon receipt, aliquot and store at -20℃ or -80℃ for long term. Avoid repeated freeze and thaw cycles.
Purified human PSA protein
Background:
Prostate-specific antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), is a glycoprotein enzyme encoded in humans by the KLK3 gene. PSA is an androgen-regulated serine protease produced by both prostate epithelial cells and prostate cancer (PCa) and is the most commonly used serum marker for cancer. It is a member of the tissue kallikrein family, some of the members of which are also prostate specific. PSA is a major protein in semen, where its function is to cleave semenogelins in the seminal coagulum. PSA is secreted into prostatic ducts as an inactive 244-amino acid proenzyme (proPSA) that is activated by cleavage of seven N-terminal amino acids. Measurement of free versus total PSA can increase specificity for PCa. PSA is also widely used to monitor responses to therapy and is under investigation as a therapeutic target.
Synonyms:
Prostate specific antigen, PSA, gamma-seminoprotein, Seminin, Kallikrein-3, P30 antigen, Semenogelase, KLK3, APS
Application: ELISA
Purity: >90% by SDS-PAGE
Formulation: Liquid
Storage buffer: Each vial contains 0.01 M PBS, 0.15 M NaCl (pH 7.4)without preservative.
Storage and Expiration:
Ship at 4℃.Upon receipt, aliquot and store at -20℃ or -80℃ for long term. Avoid repeated freeze and thaw cycles.
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