Purified Anti-Human CD16 Antibody [clone CB16]
€0.00
In stock
SKU
E-AB-F1005A
Catalog Number: E-AB-F1005A
Reactivity: Human, Clone: CB16
Isotype: Mouse IgG1, κ, Conjugation: Unconjugated
Applications: FCM
Datasheet, Questions? Contact us!
Reactivity: Human, Clone: CB16
Isotype: Mouse IgG1, κ, Conjugation: Unconjugated
Applications: FCM
Datasheet, Questions? Contact us!
Background:
CD16 is known as low affinity IgG receptor III (FcγRIII). It is expressed as two distinct forms (CD16a and CD16b). CD16a (FcγRIIIA) is a 50-65 kD polypeptide-anchored transmembrane protein. It is expressed on the surface of NK cells, activated monocytes, macrophages, and placental trophoblasts in humans. CD16b (FcγRIIIB) is a 48 kD glycosylphosphatidylinositol (GPI)-anchored protein. Its extracellular domain is over 95% homologous to that of CD16a, and it is expressed specifically on neutrophils. CD16 binds aggregated IgG or IgG-antigen complex which functions in NK cell activation, phagocytosis, and antibody-dependent cell-mediated cytotoxicity (ADCC).
Synonyms:
Low affinity immunoglobulin gamma Fc region receptor III-A, FCGR3A, CD16a antigen, Fc-gamma RIII-alpha, Fc-gamma RIII, Fc-gamma RIIIa, FcRIII, FcRIIIa, FcR-10, IgG Fc receptor III-2, CD16a
Swissprot: P08637
Buffer: PBS with 0.05% Proclin300
Concentration: 0.2 mg/mL
Storage:
Store at 2~8°C. Do not freeze.
Alternative for product with catalog number:
302001, 302002, 360701, 360702, 302051
CD16 is known as low affinity IgG receptor III (FcγRIII). It is expressed as two distinct forms (CD16a and CD16b). CD16a (FcγRIIIA) is a 50-65 kD polypeptide-anchored transmembrane protein. It is expressed on the surface of NK cells, activated monocytes, macrophages, and placental trophoblasts in humans. CD16b (FcγRIIIB) is a 48 kD glycosylphosphatidylinositol (GPI)-anchored protein. Its extracellular domain is over 95% homologous to that of CD16a, and it is expressed specifically on neutrophils. CD16 binds aggregated IgG or IgG-antigen complex which functions in NK cell activation, phagocytosis, and antibody-dependent cell-mediated cytotoxicity (ADCC).
Synonyms:
Low affinity immunoglobulin gamma Fc region receptor III-A, FCGR3A, CD16a antigen, Fc-gamma RIII-alpha, Fc-gamma RIII, Fc-gamma RIIIa, FcRIII, FcRIIIa, FcR-10, IgG Fc receptor III-2, CD16a
Swissprot: P08637
Buffer: PBS with 0.05% Proclin300
Concentration: 0.2 mg/mL
Storage:
Store at 2~8°C. Do not freeze.
Alternative for product with catalog number:
302001, 302002, 360701, 360702, 302051
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