Purified Anti-Human CD279/PD-1 Antibody [clone J116]

Background:
Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 (B7-H1) and PD-L2 (B7-DC) are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.

Research Area: Cancer, Cell Biology, Immunology

Synonyms:
PD-1, Programmed Death-1
Swissprot: Q15116

Buffer: PBS with 0.05% Proclin300

Concentration: 0.2 mg/mL

Storage:
Store at 2~8°C. Do not freeze.

Alternative for product with catalog number:
621602, 329902, 367402