Purified Anti-Mouse CD119 Antibody [clone GR-20]

Background:
CDw119 is a 90 kD immunoglobulin superfamily member, also known as IFN-γRα chain. It is a class II cytokine receptor family member that serves as a IFN-γ-binding chain associated with the IFN-γ β chain also known as AF-1. In addition to ligand binding, CDw119 participates in ligand trafficking. CDw119 is expressed on T and B cells, NK cells, fibroblasts, endothelial, and epithelial cells. Binding of IFN-γ induces receptor dimerization, internalization, Jak1 and Jak2 protein kinase activation and, ultimately, STAT1 activation. IFN-γ initiates and regulates a variety of immune responses.

Research Area: Immunology,Microbiology,Stem Cells,Kits/ Lysates/ Other

Synonyms:
Interferon gamma receptor 1, Ifngr1, IFN-gamma-R1, IFN-gamma-R-alpha, CD119
Swissprot: P15261

Buffer: PBS with 0.05% Proclin300

Concentration: 0.5 mg/mL

Storage:
Store at 2~8°C. Do not freeze.

Alternative for product with catalog number:
112802