RAC1 (clone ), anti-human, rat
€528.00
In stock
SKU
LM2177
Background:
Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion. In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning.
Alternative Name:
Ras-related C3 botulinum toxin substrate 1, Cell migration-inducing gene 5 protein, Ras-like protein TC25, p21-Rac1, RAC1, TC25, MIG5
Application Dilution: WB: 1:500~1000, IHC: 1:10~50, FCM: 1:100
Specificity: RAC1 monoclonal antibody detects endogenous levels of RAC1 protein.
Immunogen:
This antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between amino acids from human.
MW: ~ 23 kDa
Swis Prot.: P63000
Purification & Purity:
Purified antibody in PBS with 0.05% sodium azide and 0.5% protein stabilizer
Format:
Mouse IgG2b.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion. In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning.
Alternative Name:
Ras-related C3 botulinum toxin substrate 1, Cell migration-inducing gene 5 protein, Ras-like protein TC25, p21-Rac1, RAC1, TC25, MIG5
Application Dilution: WB: 1:500~1000, IHC: 1:10~50, FCM: 1:100
Specificity: RAC1 monoclonal antibody detects endogenous levels of RAC1 protein.
Immunogen:
This antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between amino acids from human.
MW: ~ 23 kDa
Swis Prot.: P63000
Purification & Purity:
Purified antibody in PBS with 0.05% sodium azide and 0.5% protein stabilizer
Format:
Mouse IgG2b.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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