RAMP2 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS7486
Background:
Receptor activity-modifying proteins (RAMPs) are transmembrane accessory proteins that influence the pharmacological profiles of the calcitonin receptor-like receptors (CRLR). RAMPs associate with CRLR in the endoplasmic reticulum and facilitate the glycosylation and transport of CRLR to the cell surface, where the mature protein then operates as a receptor for two structurally related vasodilatory peptides, calcitonin-gene-related peptide (CGRP) or adrenomedullin (ADM). RAMP-1 associating with CRLR confers a CGRP receptor, while RAMP-2 and RAMP-3 preferentially induce a responsiveness to ADM. RAMP proteins, including RAMP-1, RAMP-2 and RAMP-3, are structurally similar as they are type I receptors, which have a single extracellular N-terminus and a cytoplasmic C-terminus, and they share approximately 55% sequence similarity. RAMP-1 expression is highest in the uterus, brain and gastrointestinal tract, whereas RAMP-2 and RAMP-3 are highest in lung, breast and fetal tissues.
Alternative Name:
Calcitonin receptor like receptor activity modifying protein 2, CRLR activity modifying protein 2, OTTMUSP00000002615, OTTMUSP00000037624, Receptor (calcitonin) activity modifying protein 2, Receptor activity modifying protein 2, Receptor activity modifying protein 2 isoform, RP23-281C18.6,
Application Dilution: WB: 1:500~1:2000
Specificity: RAMP2 polyclonal antibody detects endogenous levels of RAMP2 protein.
Immunogen:
Recombinant full length Human RAMP2.
MW: ~20 kDa
Swis Prot.: O60895
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Receptor activity-modifying proteins (RAMPs) are transmembrane accessory proteins that influence the pharmacological profiles of the calcitonin receptor-like receptors (CRLR). RAMPs associate with CRLR in the endoplasmic reticulum and facilitate the glycosylation and transport of CRLR to the cell surface, where the mature protein then operates as a receptor for two structurally related vasodilatory peptides, calcitonin-gene-related peptide (CGRP) or adrenomedullin (ADM). RAMP-1 associating with CRLR confers a CGRP receptor, while RAMP-2 and RAMP-3 preferentially induce a responsiveness to ADM. RAMP proteins, including RAMP-1, RAMP-2 and RAMP-3, are structurally similar as they are type I receptors, which have a single extracellular N-terminus and a cytoplasmic C-terminus, and they share approximately 55% sequence similarity. RAMP-1 expression is highest in the uterus, brain and gastrointestinal tract, whereas RAMP-2 and RAMP-3 are highest in lung, breast and fetal tissues.
Alternative Name:
Calcitonin receptor like receptor activity modifying protein 2, CRLR activity modifying protein 2, OTTMUSP00000002615, OTTMUSP00000037624, Receptor (calcitonin) activity modifying protein 2, Receptor activity modifying protein 2, Receptor activity modifying protein 2 isoform, RP23-281C18.6,
Application Dilution: WB: 1:500~1:2000
Specificity: RAMP2 polyclonal antibody detects endogenous levels of RAMP2 protein.
Immunogen:
Recombinant full length Human RAMP2.
MW: ~20 kDa
Swis Prot.: O60895
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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