S100A1B Human Native Protein (Active)

Description:
Purified human S100A1B protein

Background:
S100 proteins, such as S100A1 (S100 calcium-binding protein A1), are small, acidic Ca(2+)-binding proteins that transduce Ca(2+) signals via interaction with intracellular target proteins. The protein encoded by this gene is a member of the S100 family of proteins containing 4 EF-hand calcium-binding motifs in its dimerized form. S100A1 is preferentially expressed in myocardial tissue and has been found to colocalize with the sarcoplasmic reticulum (SR) and the contractile filaments in cardiac tissue. Its overexpression enhances cardiac contractile performance and establish the concept of S100A1 as a regulator of myocardial contractility. S100A1 thus improves cardiac contractile performance both by regulating SR Ca(2+) handling and myofibrillar Ca(2+) responsiveness.

Application: ELISA

Formulation: Liquid

Storage buffer: Each vial contains 10 mM PBS(pH7.4).

Storage and Expiration:
Ship at 4℃.Upon receipt, aliquot and store at -20℃ or -80℃ for long term. Avoid repeated freeze and thaw cycles.