KAP1 / TIF1 beta monoclonal, anti-human
€470.00
In stock
SKU
AC-AP52671
Catalog Number: AC-AP55030
Size: 100 µl
Host: Rabbit
Applications: WB, IHC-P, IHC-F, IF, ICC, E
Datasheet
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Size: 100 µl
Host: Rabbit
Applications: WB, IHC-P, IHC-F, IF, ICC, E
Datasheet
Request Information
Background:
Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteosomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors.
Other Names:
E3 SUMO protein ligase TRIM28;E3 SUMO-protein ligase TRIM28;FLJ29029;KAP 1;KAP-1;KRAB associated protein 1;KRAB interacting protein 1;KRAB-associated protein 1;KRAB-interacting protein 1;KRIP 1;KRIP-1;KRIP1;Nuclear corepressor KAP 1;Nuclear corepressor KAP-1;RING finger protein 96;RNF96;TF1B;TIF1 beta;TIF1-beta;TIF1B;TIF1B_HUMAN; Transcription intermediary factor 1 beta;Transcription intermediary factor 1-beta; TRIM28;Tripartite motif containing 28;tripartite motif containing protein 28;Tripartite motif-containing protein 28.
Antigen Type: Recombinant Protein
Antigen Type: TRIM28 (HGNC:16384)
Gene ID: 10155
Primary Accession: Q13263
Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteosomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors.
Other Names:
E3 SUMO protein ligase TRIM28;E3 SUMO-protein ligase TRIM28;FLJ29029;KAP 1;KAP-1;KRAB associated protein 1;KRAB interacting protein 1;KRAB-associated protein 1;KRAB-interacting protein 1;KRIP 1;KRIP-1;KRIP1;Nuclear corepressor KAP 1;Nuclear corepressor KAP-1;RING finger protein 96;RNF96;TF1B;TIF1 beta;TIF1-beta;TIF1B;TIF1B_HUMAN; Transcription intermediary factor 1 beta;Transcription intermediary factor 1-beta; TRIM28;Tripartite motif containing 28;tripartite motif containing protein 28;Tripartite motif-containing protein 28.
Antigen Type: Recombinant Protein
Antigen Type: TRIM28 (HGNC:16384)
Gene ID: 10155
Primary Accession: Q13263
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