Tenascin C (clone EBS-O-166), anti-human

Source:
A BALB/c mouse was immunized with a protein preparation from a homogenate of a human breast cancer specimen.
Fusion partner: SP2/0.

Specifications:
EBS-O-166 specifically reacts with tenascin-C, an extracellular matrix glycoprotein of 210 kD. It recognizes those forms of tenascin that are produced by both normal and hyperproliferative (also neoplastic) tissues. Tenascin/hexabrachion/cytotactin is an extracellular matrix glycoprotein, widely expressed during embryogenesis. In adults, it is restricted to certain epithelial-stromal interfaces and increases markedly in hyperproliferative diseases and in stroma of many neoplasms, including gliomas, breast, squamous and lung carcinomas.

Species reactivity:
Positive: human. Negative: rat.

Applications:
Immunohistochemistry on frozen and paraffin sections.
Frozen sections: +
Paraffin sections: Tris/EDTA

Positive control: Sections of carcinomas like e.g. breast cancer. Human testis.

References:
- Verstraeten, AA et al., Br. J. Derm. 127(6), 571-574 (1992).