Tetracycline Hydrochloride

Tetracycline Hydrochloride is an antibiotic active against a wide range of gram-negative and gram-positive bacteria. The parent compound chlortetracycline was first isolated from Streptomyces aureofaciens in 1947. Soon after, other natural tetracyclines were isolated, including tetracycline, for which the family of molecules is named. The tetracyclines exert their antibiotic effect primarily by binding to the bacterial ribosome and halting protein synthesis. Upon binding the ribosome, the tetracyclines allosterically inhibit binding of the amino acyl-tRNA at the acceptor site, and protein synthesis ceases.

Advantages & Features
- Proven performance in described applications.
- Reliable: stringent quality control standards to guarantee lot-to-lot consistency.
- High Quality.

Specifications
- CAS Number: 64-75-5
- Chemical Formula: C22H25ClN2O8
- Molecular Weight: 480.90
- Appearance: Yellow powder
- Potency: >950 µg/mg
- Specific optical rotation: -240 to -255°

Includes
- 25 g Tetracycline Hydrochloride

Applications
- Used to select for TetR transformed cells or other tetracycline resistance genes.
- Tetracycline hydrochloride is used in tetracycline controlled gene expression systems (gene switches) such as the Tet-on and Tet-off systems.
- Used for the prevention of bacterial contamination of cell cultures. Recommended for use in cell culture applications at 10 mg/L.

Shipping & Storage
Shipped in: Gel pack.
Storage: 4 °C.