Thyroglobulin (clone EBS-O-192), anti-human

Source:
A BALB/c mouse was immunized with human thyroid follicular cells.

Specifications:
EBS-O-192 reacts with thyroglobulin, a 660kDa dimeric pre-protein with multiple glycosylation sites. The vast majority of follicular carcinomas of the thyroid are positive for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody.

Species reactivity:
Positive: human.

Applications:
This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to differentiate between primary thyroid and lung neoplasms.
Flow cytometry: +
Frozen sections: +
Paraffin sections: Citrate

Positive control: Human thyroid.

References:
- This antibody has not been published.