TORC1 (N-terminus) (clone ), anti-human
€388.00
In stock
SKU
MB0104
Background:
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 ´Ser-133´ phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses (By similarity)
Alternative Name:
KIAA0616, CREB regulated transcription coactivator 1, CREB-regulated transcription coactivator 1, CRTC1, CRTC1, FLJ14027, KIAA0616, MECT 1, Mucoepidermoid carcinoma translocated 1, Mucoepidermoid carcinoma translocated protein 1, TORC-1, TORC1, Transducer of CREB protein 1, Transducer of regulated cAMP response element binding protein 1, Transducer of regulated cAMP response element-binding protein (CREB) 1, Transducer of regulated cAMP response element-binding protein 1, WAMTP1, MECT1, TORC1, WAMTP1
Application Dilution: WB: 1:1000, ICC: 1:100~300, IP: 1:50~200, FC: 1:50~100
Specificity: This antibody detects endogenous levels of TORC1 and does not cross-react with related proteins
Immunogen:
Synthetic peptide, corresponding to the N-terminus of Human TORC1.
MW: Predicted band size: 69KDa , Observed band size: 69KDa
Swis Prot.: Q6UUV9
Purification & Purity:
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
Mouse IgM. Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 ´Ser-133´ phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses (By similarity)
Alternative Name:
KIAA0616, CREB regulated transcription coactivator 1, CREB-regulated transcription coactivator 1, CRTC1, CRTC1, FLJ14027, KIAA0616, MECT 1, Mucoepidermoid carcinoma translocated 1, Mucoepidermoid carcinoma translocated protein 1, TORC-1, TORC1, Transducer of CREB protein 1, Transducer of regulated cAMP response element binding protein 1, Transducer of regulated cAMP response element-binding protein (CREB) 1, Transducer of regulated cAMP response element-binding protein 1, WAMTP1, MECT1, TORC1, WAMTP1
Application Dilution: WB: 1:1000, ICC: 1:100~300, IP: 1:50~200, FC: 1:50~100
Specificity: This antibody detects endogenous levels of TORC1 and does not cross-react with related proteins
Immunogen:
Synthetic peptide, corresponding to the N-terminus of Human TORC1.
MW: Predicted band size: 69KDa , Observed band size: 69KDa
Swis Prot.: Q6UUV9
Purification & Purity:
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
Mouse IgM. Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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