UHRF1 (N-terminus) (clone ), anti-human, mouse
€388.00
In stock
SKU
MB0055
Background:
This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene.
Alternative Name:
Np95, hNP95, ICBP90, RNF106, FLJ21925, MGC138707, E3 ubiquitin-protein ligase UHRF1, Nuclear protein 95, HuNp95, hNp95, RING finger protein 106,
Application Dilution: WB: 1:1000, ICC: 1:50~200
Specificity: This antibody detects endogenous levels of UHRF1 (N-terminus) and does not cross-react with related proteins
Immunogen:
Synthetic peptide, corresponding to the N-terminus of Human UHRF1.
MW: Predicted band size: 90KDa, Observed band size: 90KDa
Swis Prot.: Q96T88
Purification & Purity:
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
Mouse IgG2b. Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene.
Alternative Name:
Np95, hNP95, ICBP90, RNF106, FLJ21925, MGC138707, E3 ubiquitin-protein ligase UHRF1, Nuclear protein 95, HuNp95, hNp95, RING finger protein 106,
Application Dilution: WB: 1:1000, ICC: 1:50~200
Specificity: This antibody detects endogenous levels of UHRF1 (N-terminus) and does not cross-react with related proteins
Immunogen:
Synthetic peptide, corresponding to the N-terminus of Human UHRF1.
MW: Predicted band size: 90KDa, Observed band size: 90KDa
Swis Prot.: Q96T88
Purification & Purity:
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
Mouse IgG2b. Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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