CD144 (VE-Cadherin) polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS70310
Background:
The cadherins are a family of Ca 2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. Cadherins each contain a large extracellular domain at the amino-terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short carboxy-terminal, intracellular domain interacts with a variety of cytoplasmic proteins, including β-catenin, to regulate cadherin function. VE-cadherin (for vascular endothelial cadherin, also designated cadherin-5) is localized at intercellular junctions of endothelial cells, where it is thought to play a role in the cohesion and organization of intercellular junctions.
Alternative Name:
CDH5, Cadherin-5, 7B4 antigen,VE-Cadherin, Vascular endothelial cadherin ,CD144,
Application Dilution: WB: 1:500 - 1:1000
Specificity: VE-Cadherin polyclonal antibody detects endogenous levels of VE-Cadherin protein.
Immunogen:
Recombinant protein of human CDH5.
MW: ~ 88 kDa
Swis Prot.: P33151
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The cadherins are a family of Ca 2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. Cadherins each contain a large extracellular domain at the amino-terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short carboxy-terminal, intracellular domain interacts with a variety of cytoplasmic proteins, including β-catenin, to regulate cadherin function. VE-cadherin (for vascular endothelial cadherin, also designated cadherin-5) is localized at intercellular junctions of endothelial cells, where it is thought to play a role in the cohesion and organization of intercellular junctions.
Alternative Name:
CDH5, Cadherin-5, 7B4 antigen,VE-Cadherin, Vascular endothelial cadherin ,CD144,
Application Dilution: WB: 1:500 - 1:1000
Specificity: VE-Cadherin polyclonal antibody detects endogenous levels of VE-Cadherin protein.
Immunogen:
Recombinant protein of human CDH5.
MW: ~ 88 kDa
Swis Prot.: P33151
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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