Xgrinder™ Portable 3D Homogenizer

Xgrinder™ 3D Homogenizer

Xgrinder™: High-Performance Portable Homogenizer for Tough Samples
OnsiteGene's Xgrinder™ is a compact, high-speed 3D bead homogenizer engineered for efficient sample disruption and lysis. Its lightweight, portable design makes it an ideal tool for labs working with a wide range of sample types—including blood, tissues, plants, fungi, and Gram-positive bacteria.

Designed for seamless integration with the Xtractor™ system, Xgrinder™ enhances nucleic acid extraction workflows by delivering effective pre-processing and improved homogenization. This powerful combination boosts nucleic acid yield and purity, improving accuracy and efficiency in downstream applications—especially when handling challenging samples like fungi and Gram-positive bacteria.

Xgrinder™ Performance Advantage
The Xgrinder™ 3D grinding motion delivers the highest nucleic acid yield across all tested pathogens—including Gram-positive bacteria and fungi—outperforming vortex beating, enzymatic digestion, and 2D grinding methods. With a processing time of just ~4 minutes, Xgrinder™ significantly reduces workflow time compared to enzyme lysis (~15 minutes) while providing up to 4.3× greater yield.
In whole blood (WB) samples, Xgrinder™ achieved the lowest Ct values, indicating higher nucleic acid concentrations. The observed ΔCt improvements (ranging from 2.38 to 4.28) reflect substantial gains in extraction efficiency and pathogen detectability.
These results establish Xgrinder™ as the optimal tool for rapid, high-efficiency nucleic acid extraction, especially for tough-to-lyse organisms—making it ideal for time-sensitive diagnostic and research applications.

Key Product Highlights of Xgrinder™
· 3D Grinding Motion - Unique figure-8 oscillation for thorough and uniform homogenization.

· Ultra-Fine Grinding - Reduces particle sizes to ≤5μm — ideal for high-yield nucleic acid extraction.

· Flexible Grinding Modes & Multi-Sample Processing - Compatible with wet and dry grinding, and various tube formats.

· Versatile Sample Compatibility - Suitable for DNA, RNA, and protein extraction from diverse sample types.

· High Grinding Speed & Precision Control - Up to 5,500rpm, adjustable in 1 rpm increment, reaching target speed within 1 second.

· Advanced Shock Absorption - Dual-damping system reduces vibration for quiet, stable operation.

· Flexible Power Supply - Direct AC or 24V DC mobile power (e.g., power bank) for uninterrupted lab use.

· Compact & Lightweight - Only 5.3 kg in weight with a footprint of 240 × 240 × 240mm — portable and easy to store.


Xgrinder™ Instrument Specifications
· Grinding Motion: 3D motion mode with a figure-8 trajectory
· Speed Range: 0–5,500 rpm (adjustable in 1 rpm increments)
· Sample Capacity: 12×2 ml, 16×2 ml, 24×2 ml; 12×5 ml, 6×5 ml, 8×5 ml (customizable for specific experimental needs)
· Particle Size Output: ≤5 µm
· Operating Conditions: Temperature 0–42 °C, Humidity 5–95%
· Safety Features: Safety lock and automatic stop when the lid is open
· Noise Level: ≤ 62.4 dB(A)
· Interface: Touchscreen with operational prompts
· Programmable Settings: Grinding time (0–9999 sec), interval time (0–9999 sec), cycle count (0–99)
· Custom Programs: Supports user-defined protocols
· Program Storage: Up to 20 pgrograms
· Weight: 5.3 kg
· Dimensions (W×D×H): 240x240x240 mm

Software
The software is designed for seamless and efficient operation. Integrated directly within the instrument, it features an intuitive interface for straightforward operation, allowing users to effortlessly customize grinding protocols. The software is also built to accommodate on-demand upgrades, ensuring that your system remains at the forefront of technology. For a comprehensive understanding of all the features and step-by-step guidance, users are encouraged to consult the detailed user manual.

Bead Tubes
Xgrinder™ Bead Tubes – Versatile, Pre-Filled, and Sample-Optimized
Xgrinder™ bead tubes are engineered for high-efficiency sample homogenization across a wide range of biological and environmental sample types. Each tube is pre-filled with optimized beads—ceramic, zirconia, stainless steel, or custom—tailored for specific sample properties, from soft tissues to hard materials.

Applications include:
· Tissue & Biopsy Samples: Ceramic beads (BCT-1) for soft animal or plant tissues.
· Bacteria (Gram+/-): Zirconia beads (BCT-2) for robust microbial cell disruption.
· Fungi & Spores: Zirconia beads (BCT-3) for tough fungal walls.
· Plant Materials: Ceramic beads (BCT-4) for roots, leaves, and seeds.
· Hard Samples: Stainless steel beads (BCT-5) for bone, tooth, and wood.
· Soil & Sediment: Mixed beads (BCT-6) for environmental samples.
· Fecal Samples: Zirconia beads (BCT-7) optimized for stool.
· Custom Needs: BCT-8 for user-defined bead configurations.

Key Features:
· Pre-filled and ready-to-use (no pre-processing required)
· Autoclavable and DNA/RNA-free certified (optional)
· Available in 2 mL and 5 mL volumes for flexible input