HCV-Core polyclonal, anti-virus

Protein Family: Ribosomes

Pathway and Disease: Cancers, Cell Growth and Death, Immune System, Infectious Diseases, Lipid Metabolism, Signaling Molecules and Interaction, Transcription

Description:
The p21 core protein from Hepatitis C virus (HCV) packages viral RNA to form a viral nucleocapsid and promotes virion budding . p21 modulates viral translation initiation and regulates many host cellular activities by interacting with HCV IRES and 40S ribosomal subunit. p21 also regulates host cellular functions that prevent the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways and by inducing human STAT1 degradation. p21 plays an important role in the virus-mediated cell transformation leading to hepatocellular carcinomas.

Alternate Names: Genome polyprotein Hepatitis C virus, Core protein p21, Core protein p19, HCV Capsid protein C

Application Notes: E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500; IF: 1:100-1:500

Accession No.: P26664

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of HCV p21 core protein.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Product Citations:
Islam MJ et al. 2015. Biomed Res. 36(3): 159-167. PMID# 24749543.